Technical Publications
Note: PPCM Aka SAMMA
Mandelic Acid Condensation Polymer: Novel Candidate Microbicide for Prevention of Human Immunodeficiency Virus and Herpes Simpex Virus Entry. Herold BC, Klotman ME, et al. J Virol. 2002 Nov;76(22):11236-44. doi: 10.1128/jvi.76.22.11236-11244.2002. PMID: 12388683; PMCID: PMC136750.
Use of mandelic acid condensation polymer (SAMMA) a new antimicrobial contraceptive agent, for vaginal prophylaxis. Zaneveld LJ, Herold B, et al. Fertil Steril. 2002 Nov;78(5):1107-15. doi: 10.1016/s0015-0282(02)04210-3. PMID: 12414002.Lourens J.D. Zaneveld et al Fertility and Sterility, vol. 78, No. 5, November 2002
Candidate Topical Microbicides Bind Herpes Simplex Virus glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread. Natalia Cheshenko et al, Antimicrobial Agents and Chemotherapy, June 2004, p. 2025-2036
SAMMA Induces Premature Human Acrosomal Loss by Ca2+ Signaling Dysregulation. Anderson RA et al, Journal of Andrology 2006 27:568-577
SAMMA a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. Chang T. et al, FEBS Letter 2007 581:4596-4602
Candidate Microbicides PPCM Blocks Human Immunodeficiency Virus type I Infection in Cell and Tissue Cultures and Prevent Genital Herpes in a Murin Model. Mesquita P. et al, Journal of Virology 2008 82:6576-6584
Polyphenylene carboxymethylene (PPCM) in vitro antiviral efficacy against Ebola virus in the context of a sexually transmitted infection. Escaffre O, Juelich T, Freiberg Antiviral Res 170 2019
Feasibility of Repurposing the Polyanionic Microbicide, PPCM, for Prophylaxis against HIV Transmission during ART. Anderson R. et al, ISRN Obstetrics and Gynecology, Vol 2011, ID 524365
Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development. Weitzel M, North BB, Waller DP Biol Reprod. Aug 4;103(2):299-309.
Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays. Barbara B North et al Andrology 20 September 2021
Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-CoV-2. Proof of concept in primary human undifferentiated epithelial cells Antiviral Research 2021; Aug 9
Polyphenylene carboxymethylene (PPCM), the Active Component of the topical contraceptive, Yaso-Gel, exhibit potent antimicrobial activity against Neisseria gonorrhoeae in preclinical studies. Pilligua-Lucas M, Tkavc R, Bash SK, et al. Sex Transm Infect 2023;99:409–415.
